3D Printing of Bone Grafts for Cleft Alveolar Osteoplasty:

Cleft lip and cleft alveolar bone defects are congenital anomalies. They often require surgery during infancy and early childhood. Scientists of the Berlin Charité, the Dresden Technical University and the Zurich University conducted a promising animal study with rats. 3D-printed bone grafts with CPC (Calcium Phosphate Cement) were used. Their paper outlines two main benefits to traditional therapies: CPC grafts are resorbable – the young patients are still in the growth phase – and 3D printing allows implants with patient-specific geometry. The GeSiM bioprinter BS3.1 was used for this study. The grafts consist of Calcium-Phosphate-Cement (CPC) of the manufacturer Innotere. Mesenchymal stromal cells of the rats were incubated with the grafts to improve their growth behaviour. The full publication is available for download.

Empty defect of the cleft [1]

Empty defect of the cleft [1]

Filled defect with a precisely fitting scaffold [1]

Filled defect with a precisely fitting scaffold [1]

[1]: 3D Printing of Bone Grafts for Cleft Alveolar Osteoplasty – In vivo Evaluation in a Preclinical Model, Paula Korn et.al., frontiers in Bioengineering and Biotechnology, 25th March 2020