Core/Shell Extruder

Artificial Tissue from Maccaroni Strands

Core/Shell Extruder with cartridges for two separate materials; Deactivating the core extruder allows hollow fibres (Left)

Core/Shell Extruder with cartridges for two separate materials; Deactivating the core extruder allows hollow fibres (Left)

Layered stack of hollow fibres

Layered stack of hollow fibres

CoreShell Extruder with Core (Orange) and Shell (Green) Material - Schematic View

CoreShell Extruder with Core (Orange) and Shell (Green) Material – Schematic View

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Soft matrices like Hydrogels are cell friendly materials but hard to print into stable 3D structures. The combination with more stiff thermoplastic scaffolds may cause biocompatibility issues.The pneumatic C/S-extruder (Core/Shell extruder) for BS printers allow to combine two materials with different properties in a coaxial manner. The tool is equipped with a kind of double nozzle with different but corresponding inner and outer diameter, respectively. The print parameters can be set individually for both channels in order to match properties of the respective bioinks.

 

Core/Shell strand with cells inside after 7 days cultivation: Bright field image (left); Nuclei stained blue (right)

Core/Shell strand with cells inside after 7 days cultivation: Bright field image (left); Nuclei stained blue (right) (1)

 

 

 

 

 

A. R. Akkineni, T. Ahlfeld, A. Lode and M. Gelinsky: A versatile method for combining different biopolymers in a core/shell fashion by 3D plotting to achieve mechanically robust constructs, IOP Publishing Ltd., Oct 2016


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Centre for Translational Bone, Joint and Soft Tissue Research
Technische Universität Dresden