A Versatile Microfluidic System

Selected Applications

The MicCell System gained much attention from researchers world wide. Here we present a list of applications already done. Please contact us for further details.

  • Micro-reaction technology, e.g., hybridization or stoppedflow chamber, using fluorescence detection
  • Immobilization of biomolecules (e.g., protein or DNA) in the microchannels before assembly, e.g., by microarraying
  • Generation of concentration gradients perpendicular to the microchannel cross section by a “gradient mixer”
  • Semi-automatic drug screening using adherent cells or tissue slices
  • Viability tests and other cell-based physiological assays
  • Measurement of the interaction of cells with immobilized proteins, DNA, RNA, oligo- or polysaccharides, lipids, and other ligands
  • Cell handling and sorting using optical tweezers
  • Identification of cancer or stem cells using an “optical stretcher” (patent University of Leipzig)
  • Electroporation in the flow
  • Testing of the uniformity of microbeads and other particles, potentially with sorting
  • Manipulation of elongated macromolecules (e.g., DNA or motor proteins) in hydrodynamic flow fields for the bottom-up construction of nanostructures, force measurements, etc.
  • Micro-capillary electrophoresis under the microscope
  • Integration of, e.g., column or filtration material for micro-purifying with or without microscope control
  • Liquid processing independent of a microscope (e.g., assays using electrochemical detection)
    Chemical synthesis on the nanoscale
  • Observation of opaque objects in the MicCell using the pivotable sample carrier