Multi-Material Scaffolds

BioInks fill the gap between a 3D printer and tissue engineering

Bioscaffold consisting of struts of two different material: Calciumphosphate and Alginate

Bioscaffold consisting of struts of two different material: Calciumphosphate and Alginate

 

Biopolymers for cell cultivation usually show a low viscosity. 3D structures of defined shape, however, require stiff materials with low cell viability potential. An contradiction in terms?

The picture presents one possible approach: Composites of two or three materials give home to cells in a “stiff” 3D environment.

Combined printing of very different polymers can be challenging for the printer: Different needle sizes, different print parameters for each needle. All this is available with BS3.1

 

 

 

 

Up to now commercial bioinks are expensive and not always working in a suitable manner. Our RESOURCES section lists publications of GeSiM customers/ partners working on biomaterials. Examples:

  • Researchers at Technical Universität Dresden show how low-viscous alginate turns into a valuable bioink by adding Methylcellulose. (More…)
  • A blend of PCL-PEG with ADA (Dialdehyde gelatine hydrogel) was investigated by the Biomaterial Resarch Group at FAU Erlangen. (More…)
  • VELOX(R) bone substitute cement paste is based on calcium-phosphate and now commercially available from INNOTERE GmbH, Radebeul, Germany.

 

BS3.1 now is probably the worlds only bioprinter with built-in two-component extruder: A so called Core/Shell extruder produces “maccaroni” structures, e.g. for direct combination of a soft, cell-friendly polymer with an alginate of much higher viscosity.

 

 

Two component silicone scaffold with integrated channel, held open by sugar paste (green).

Two component silicone scaffold with integrated channel, held open by sugar paste (green).

Multi layer scaffold from differently colored silicone

Multi layer scaffold from differently colored silicone