BioInks fill the gap between a 3D printer and tissue engineering
Biopolymers for cell cultivation usually show a low viscosity. 3D structures of defined shape, however, require stiff materials with low cell viability potential. An contradiction in terms?
The picture presents one possible approach: Composites of two or three materials give home to cells in a “stiff” 3D environment.
Combined printing of very different polymers can be challenging for the printer: Different needle sizes, different print parameters for each needle. All this is available with BS3.1
Up to now commercial bioinks are expensive and not always working in a suitable manner. Our RESOURCES section lists publications of GeSiM customers/ partners working on biomaterials. Examples:
- Researchers at Technical Universität Dresden show how low-viscous alginate turns into a valuable bioink by adding Methylcellulose. (More…)
- A blend of PCL-PEG with ADA (Dialdehyde gelatine hydrogel) was investigated by the Biomaterial Resarch Group at FAU Erlangen. (More…)
- VELOX(R) bone substitute cement paste is based on calcium-phosphate and now commercially available from INNOTERE GmbH, Radebeul, Germany.
BS3.1 now is probably the worlds only bioprinter with built-in two-component extruder: A so called Core/Shell extruder produces “maccaroni” structures, e.g. for direct combination of a soft, cell-friendly polymer with an alginate of much higher viscosity.