Synthesis of Hydrogels

The Promise of Water containing Hydrogels

Hydrogels are widely used in regenerative medicine. The soft and water containing polymers are well appropriated as cell culture media but keep cells “in shape”: 3D printing arranges the hydrogel in a spatial manner or allows combined printing with other polymers.

In collaboration with the Leibniz Institute for Polymer Research Dresden a configuration for Hydrogel synthesis was developed. It starts with the conjugation of Polyethylene Glycol (PEG) with crysteine-containing peptides such that the conjugate contains a terminal thiol group. At the same time, heparin is coupled with reactive groups, all in an automated way. The PEG-peptide-thiol polymer is then linked to the heparin via a sulphur bridge, and other components (cells, adhesive peptides) are added. Star-hydrogels are possible.

The GeSiM BioScaffold printer is well appropriated for 3D prints with hydrogels. Please visit the related product site for BS3.1.