Here we present a general overview of bioprinter applications and printable materials for the GeSiM BioScaffolder instruments.
Melt Electro Writing of Milk Protein/PCL Blends for Skin Regeneration
The influence of milk proteins on the properties of PCL was investigated by the Department of Chemistry at the University of Otago, New Zealand. Special focus was put on the Melt Electro Writing unit of the GeSiM bioprinter BioScaffolder 3.1. The used milk proteins, Lactoferrin and Whey Protein, are supposed to increase the biological functionality of PCL.
PCL-PEG Blends for Tissue Engineering
A customer at Friedrich-Alexander University Erlangen (FAU) succeeded in improving the properties of PCL for tissue engineering by adding PEG. These biopolymers shall be optimized towards a quicker degradation/mass loss when getting in contact with body fluid.
Struts and Capsules
A group from the FAU Erlangen added prefabricated capsules enriched with cells to hydrogels before printing. Different components desirable for bone regeneration, e.g., cells and bioactive proteins, can be incorporated both in the capsules and struts. This enables compartmentalization of components, which facilitates greater flexibility in modification of the scaffold.
A team from the Technische Universität Dresden printed algae cells suspended in hydrogel together with mammalian cells. The cocultivation of algae in close vicinity to human cells could enable a sustained delivery of oxygen or secondary metabolites with therapeutic potential to human cells without the need of external supply. The fabrication of patterned coculture scaffolds can be easily realized by two-channel plotting.
Immediate cross linking of alginate after printing can be avoided – Accordingly to an approach of researchers at the Technische Universität Dresden. The addition of Methylcellulose (MC) to low concentrated alginate leads to an enhanced viscosity and therefore improved printing conditions.
Bioprinting: The Future of Surgery?
In a joint research project with the Technische Universität Dresden a scaphoid bone scaffold model was printed from Calcium Phosphate Cement. As model the human scaphoid bone was selected and 3D data extracted from a CT scan.
As FAST as Possible
An EU funded Consortium (Horizon 2020) was setup to optimize bulk and surface properties of scaffold materials for implants. GeSiM has been engaged for the development of high-performance syringe extruders for printing of polymer gradients through a single tool and within one layer. Further GeSiM adapts the NADIR plasma pen onboard of the BioScaffold printer, it now synchronizes with all other GeSiM bioprinter tools