BioScaffold Printer 3.3 Prime

The BS3.3 Prime is the new affordable bioprinter from GeSiM, including a set of tools for easy printing of most popular bioinks. It comes with the full software package known from the larger GeSiM bioprinters.

Versatility Matters!

Different biopolymers require different extrusion methods:  This BioScaffold Printer BS5.1 is configured with temperature controlled pneumatic extruder, Nanolitre pipetting and mechanical piston extruder.

BioScaffold Printer 5.1/E

BS5.1/E - This bioprinter is the "working horse" for tissue engineering at production scale. It's powerful but silent motion system combines accuracy with 24/7 reliability.

BioScaffold Printer 3.2

The BioScaffolder 3.2 get's your cells in shape! This bioprinter accepts many bioinks and meltable polymers. Learn how to evolve your petri dish cell culture into an artificial piece of bone or skin.

Thin mesh printed by the MEW tool

Melt Electro Writing

High-voltage induced deposition of biopolymer fibres creates attractive growth environments for cells. (Image with courtesy from Dr. Cathal O'Connell, BioFab3D, St Vincent's Hospital Melbourne, Australia)

Algae Laden Scaffolds

Greetings from the plant kingdom: Chlamydomonas reinhardtii (Algae cells) peaceful coexists with human cells printed into an alginate/hydrogel scaffold. Courtesy of Centre for Translational Bone, Joint and Soft Tissue Research

Struts and Capsules

Fluorescence image of cell loaded Alginate capsules after printing with the GeSiM Bioscaffold printer. Courtesy of Institute of Biomaterials, Erlangen.

Development of Artifical Womens Breast

based on PCL-scaffolds. Tissue is regenerated by injecting patient-derived fat cells into the scaffold pores (Bellaseno GmbH).

The New Egg Style for Breakfast?

A thin mesh from PCL 50.000 was printed on a solid support. After detaching the flexible mesh can be moved. It adheres easily to the curved surface of the egg.

3D Bioprinters – The Modular Solution for Tissue Engineering from GeSiM

Customizable 3D-Bioprinters

Additive manufacturing (AM) for tissue engineering (TE) and regenerative medicine combines biocompatible/biodegradable polymers with living cells. GeSiM 3D bioprinters can create bioscaffolds for cell growth or deposit layers of bioinks on implants or microfluidic objects. However, artificial bones, skin, organoids still not reach their originals made by nature. Research on this subject requires flexible lab equipment, compatible even with new tools and accessories still to be developed.

Our bioprinters offer this level of versatility. Pneumatic extrusion is on board of each GeSiM bioprinter, numerous tools can be configured with your order or added years later. The user interface fits into this philosophy and adapts to each individual combination of tools.

Most extrusion tools fit to all GeSiM instruments. The combination of 3D printed scaffolds with Nanolitre pipetting and microfluidics extends the field of TE to drug discovery, cell biology and more.

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Applications at a Glance:

  • 3D Printing of very different (Bio-)polymers (can contain cells)
  • Design and print of porous – multi material – structures for tissue engineering
  • Co-printing of hard (E.g. PCL/PLA) and soft (E.g. Alginate) biopolymers (Sequential printing, co-axial extrusion, Nanolitre pipetting)
  • Functionalization of metal implants with soft polymer layers
  • Printing of micro structures from biopolymers by melt electro spinning/writing
  • Co-printing of two polymer melts through a gradient mixer

Don’t miss the tab CUSTOMER REFERENCES outlining selected customer projects.

Instruments

BS3.3 Prime

The choice for beginners with potentially growing demands.

It is an attractively priced but complete bioprinter package:

  • One temperature-controlled print head,
  • LED UV-light, different wave lengths available,
  • Pneumatic and mechanical extrusion,
  • Syringe volumes from 10…50 Millilitres.

It prints a wide range of Hydrogels, Alginates and low-melting polymers like certain PCLs.

BS3.3

BS3.3 and it’s predecessors are in use for years in labs which paved the way for tissue engineering.

It is an individually configurable bioprinter for cutting-edge research. The range of available extrusion tools accepts almost any polymer of potential use in the field of TE.  It combines highest flexibility with compact dimensions and fits in many popular biosafety cabinets.

BS5.1

It’s the perfect companion for large research teams, core facilities and service providers with 24/7 operation.

BS5.1 comes with extremely powerful linear motors. This bioprinter can run unrivalled systems for gradient mixing of thermoplastic biopolymers during the print, in addition to all other extrusion tools.

BS5.1/E

The largest GeSiM bioprinter tops our  portfolio.

BS5.1/E offers almost double print bed size than all other bioprinters. The X/Y printing range is probably the largest on the market of commercial bioprinters. Customized object holders for batch production are available, please ask.

Smart Technology for Efficient Use

Internal design of a scaffold structure of two different material: Calciumphosphate and Alginate.

Internal design of a scaffold structure of two different material: Calciumphosphate and Alginate.

  • Silent but smart XYZ-drives with Micrometer precision, individually Z-axes for print tools and optical components
  • Decentralized units for printing, media control and computing save your precious space in biosafety cabinets and ensure superb heat dissipation
  • Same software for all GeSiM bioprinters with easy to use CAD import
  • UV-light sources of different intensity/ costs on the print head; camera systems
  • Standard plastic cartridges as well as all Luer- lock nozzles can be used on all GeSiM bioprinters for 3d prints at room temperature
  • Automatic alignment of all nozzle sizes to the building platform
  • Print beds for SBS well plates with easy click fixation, temperature control and customized layouts available on request

GeSiM bioprinters are easy to operate in routine use:

Fully automatic adjustment of nozzles to the print bed (Left), the print bed size of BS5.1 (Right) fits to at least four SBS well plates or equivalent objects.

Nanolitre Pipetting

Tissue Engineering often raises interface and surface questions: How do cells adhere to artificial bones, implants and similar objects? What is the optimum scaffold geometry/ scaffold material to achieve appropriated cell adherence? Which cell line works, which doesn’t? Just throwing your ready-printed 3D object into a petri dish with cell suspension? – The Nanolitre pipetting module applies cells with spatial resolution during printing. Design and realization of complex artificial tissue with several cell types – partially applied to different parts of your 3D structure – becomes feasible.

The GeSiM Nanolitre Pipetting module allows up to 96 different cell suspensions or protein solutions for embedding into 3D structures during printing.

  • CAD – based tethering of cells/proteins to parts of a 3D structure during printing,
  • Volumes <100 Microlitres per species save resources when using rare and expensive samples,
  • Onboard washing allows subsequent liquid handling of different species with one tool,
  • Dispense volume ranges from 0.1 Nanolitre to Microlitres,
  • Twin adapter for micro pipets enables parallel aspiration of two species with subsequent droplet mixing at the target position.

Refer to the tab PRINT TOOLS for technical information on available dispensers.