Long-Lasting Ocular Implants for Posterior Eye Diseases: Visual impairment and blindness are becoming a global issue due to their significant effects on social interactions and economic development. Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are retinal disorders that are the main factors leading to blindness and vision impairment. As the elderly and diabetic populations [...]
Refining RPPA Techniques for Accurate Quantification of Phosphoproteins in Solid Tissues: The Reverse Phase Protein Array (RPPA) is a robust technique for quantitative proteomics, particularly useful for profiling post-translational modifications (PTMs) in finite tissue samples such as those from patients. Despite efforts to optimize tissue-based RPPA applications, technical challenges remain, including the validation of RPPA-applicable [...]
3D Bioprinted Breast Cancer Models for Enhanced Drug Testing and Metabolic Studies: Despite advancements in modeling the complex tumor microenvironment, conventional breast cancer models often fall short in providing accurate insights into cancer biology and drug efficacy. Accurately modeling this environment could improve the efficacy and safety of cancer treatments by offering more accurate preclinical [...]
Efficient Microalgae Separation Using Dielectrophoresis in a Microfluidic Flow Cell: Microalgae are a valuable source of poly-unsaturated fatty acids, which are applied in various biotechnological fields such as pharmaceuticals and food supplements. Separating microalgae cells based on their lipid content could be relevant for at-line analytical techniques and strain selection. In a study done by [...]
Advancing Cancer Research with 3D Bioprinting Realistic Models: Cancer progression is influenced by complex interactions between cancer cells and their surrounding stromal environment. Traditional 2D cell cultures and animal models have limitations in capturing this complexity. Therefore, researchers are increasingly adopting 3D in-vitro models that more accurately mimic the tumor microenvironment. A team of researchers [...]
Bioink for 3D-Bioprinting with Decellularized Bone Particles: Biofabrication is a technology that uses extrusion printing methods to create three-dimensional (3D) living tissue structures. One of the key challenges in biofabrication is maintaining the shape fidelity of the 3D-printed constructs while allowing cell proliferation. Material characteristics directly affect printability, shape fidelity, and cell behavior post-bioprinting. Gelatin [...]
Controlled Release of Growth Factors in Bioprinted Respiratory Scaffolds: Tissue engineering is a rapidly evolving field that seeks to stimulate and control tissue generation and regeneration by incorporating cells, biocompatible materials, and bioactive molecules. Both the mechanical and chemical environments provide cues and signaling factors that significantly influence cellular development. Among these, growth factors are [...]
Tissue Engineering with combination of FDM and MEW: Patient-specific treatments have become increasingly crucial in modern medicine. As personalized care gains prominence, the demand for innovative technologies to fulfill these requirements has arisen. Enter additive manufacturing (AM)—a promising solution that holds immense potential. Researchers at the University of Otago aimed to combine two additive manufacturing [...]
Transforming Tendon Reconstruction: The GeSiM BioScaffolder's Role in Hybrid Scaffold Innovation Tendons are connective tissues that attach muscles to bones and enable joint movement. However, tendon injuries are common and often difficult to heal, requiring surgical intervention with autologous materials and long-term rehabilitation. The use of regenerative grafts, which mimic mechanical properties while supporting the [...]
Revolutionizing Food Safety: Lab-in-a-Package: In a world where food safety is essential, a paper published by researchers at the McMaster University (CA), GeSiM’s customer, introduces a game-changing solution: Lab-in-a-Package. This innovative approach aims to transform the way we detect and prevent foodborne illnesses, offering a hands-free, real-time method within the confines of a closed food [...]
