Precise DNA-Based Analysis for Pathogen Identification in Laboratory Medicine: The team of Cube Dx gathered experience with various technologies and instruments for DNA microarray production for laboratory medicine. Cylindrical microarrays – hybcells – are the core product of the IVD company. Cube Dx’ hybcells are a tool for sensitive and specific DNA-based identification of more [...]

Integrating FDM and Inkjet Printing for Personalized Drug-Loaded Tablets: The pharmaceutical field has witnessed a surge of interest in 3D printing (3DP) technologies, celebrated for their ability to create personalized, cost-effective, and complex oral dosage forms. Following the FDA’s approval of Aprecia Pharmaceutical’s Spritam® (levetiracetam) as the first 3D-printed tablet, the industry’s fascination with printable [...]

Long-Lasting Ocular Implants for Posterior Eye Diseases: Visual impairment and blindness are becoming a global issue due to their significant effects on social interactions and economic development. Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are retinal disorders that are the main factors leading to blindness and vision impairment. As the elderly and diabetic populations [...]

Refining RPPA Techniques for Accurate Quantification of Phosphoproteins in Solid Tissues: The Reverse Phase Protein Array (RPPA) is a robust technique for quantitative proteomics, particularly useful for profiling post-translational modifications (PTMs) in finite tissue samples such as those from patients. Despite efforts to optimize tissue-based RPPA applications, technical challenges remain, including the validation of RPPA-applicable [...]

3D Bioprinted Breast Cancer Models for Enhanced Drug Testing and Metabolic Studies: Despite advancements in modeling the complex tumor microenvironment, conventional breast cancer models often fall short in providing accurate insights into cancer biology and drug efficacy. Accurately modeling this environment could improve the efficacy and safety of cancer treatments by offering more accurate preclinical [...]

Efficient Microalgae Separation Using Dielectrophoresis in a Microfluidic Flow Cell: Microalgae are a valuable source of poly-unsaturated fatty acids, which are applied in various biotechnological fields such as pharmaceuticals and food supplements. Separating microalgae cells based on their lipid content could be relevant for at-line analytical techniques and strain selection. In a study done by [...]

Advancing Cancer Research with 3D Bioprinting Realistic Models: Cancer progression is influenced by complex interactions between cancer cells and their surrounding stromal environment. Traditional 2D cell cultures and animal models have limitations in capturing this complexity. Therefore, researchers are increasingly adopting 3D in-vitro models that more accurately mimic the tumor microenvironment. A team of researchers [...]

Bioink for 3D-Bioprinting with Decellularized Bone Particles: Biofabrication is a technology that uses extrusion printing methods to create three-dimensional (3D) living tissue structures. One of the key challenges in biofabrication is maintaining the shape fidelity of the 3D-printed constructs while allowing cell proliferation. Material characteristics directly affect printability, shape fidelity, and cell behavior post-bioprinting. Gelatin [...]

Tissue Engineering with combination of FDM and MEW: Patient-specific treatments have become increasingly crucial in modern medicine. As personalized care gains prominence, the demand for innovative technologies to fulfill these requirements has arisen. Enter additive manufacturing (AM)—a promising solution that holds immense potential. Researchers at the University of Otago aimed to combine two additive manufacturing [...]