Peptide Chitosan/Dextran Core/Shell vascularized 3D Constructs for Wound Healing:
Vascularization is still a challenge when creating artificial tissue by 3D printing. New Zealand researchers successfully put a step forward using the core/shell extruder of the GeSiM bioprinter BS3.1. This tool prints two different materials in a coaxial manner. The team at University of Otago used a bioink with hBMSC stem cells in the shell lane and another biopolymer with endothelial cells in the core lane. In the end microvascularization could be observed. The 3D bioprinted c/s construct made with custom peptide functionalized biomaterials provided a safe delivery vehicle for BMSCs and endothelial cells while providing the appropriate microarchitecture for the early development of vascular, tube-like structures. A first publication is available.
Courtesy of: Jaydee Cabral, University of Otago, New Zealand
Paul R. Turner, Eoin Murray, C. John McAdam, Michelle A. McConnell, and Jaydee D. Cabral
ACS Applied Materials & Interfaces Just Accepted Manuscript 28 June 2020